RANOLIFE 500mg Tablet 10’s

RANOLIFE 500mg Tablet 10’s

INTRODUCTION:-

RANOLIFE 500MG TABLET contains Ranolazine which belongs to theroup of medicines called Antianginals. It is used to treat chronic angina.

Angina pectoris can be defined as a sudden, sharp and severe chest pain that originates from the apex of the heart and radiates to the left shoulder. It can be characterized by the presence of severe and crushing pain along with a feeling of pressure and suffocation, especially behind the breastbone.

RANOLIFE 500MG TABLET is not recommended for use in patients with severe kidney disease, moderate to severe liver disease. Contact your doctor before taking.

RANOLIFE 500MG TABLET should be used with caution in patients with mild to moderate kidney disease, mild liver disease and moderate to severe heart failure, abnormal ECG changes like like QT prolongation or long QT syndrome. Contact your doctor before taking.

RANOLIFE 500MG TABLET isenerally not recommended for use in pregnant women unless considered clearly necessary. Contact your doctor before taking. RANOLIFE 500MG TABLET is not recommended for use in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before taking it.

RANOLIFE 500MG TABLET is not recommended for use in children and adolescents under 18 years of age. Contact your doctor before taking.

RANOLIFE 500MG TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking.

Avoid drinkingrapefruit juice as it may lead to unwanted effects. The most common side effects of taking RANOLIFE 500MG TABLET are nausea, vomiting, constipation, dizziness headache and weakness. Contact your doctor if any of the above side effects worsen.

USES OF RANOLIFE 500MG TABLET:-

Used to treat chronic angina

HOW RANOLIFE 500MG TABLET WORKS:-

RANOLIFE 500MG TABLET works by inhibiting the entry of sodium and potassium into the heart cells, thereby preventing the calcium influx causing vasodilation and reduces ventricular tension, myocardial oxygen demand. Thus, relieving angina symptoms.

DIRECTIONS FOR USE:-

Take RANOLIFE 500MG TABLET as advised by your physician. Swallow the medicine with alass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF RANOLIFE 500MG TABLET:-

• COMMON

Nausea, vomiting
Constipation
Dizziness
Headache
Weakness

• UNCOMMON

Altered sensation
Anxiety
Difficulty sleeping
Confusion
Hallucination
Blurred vision, visual disturbance
Changes in sensation (touch or taste)
Tremors
Feeling tired or sluggish
Sleepiness or drowsiness
Fainting
Dark urine, blood in urine, difficulty in urination
Difficulty in breathing
Cough, nose bleed
Excessive sweating, itching
Feeling swollen or bloated
Hot flushes, low blood pressure
Increase in creatinine
Increase in urea in blood
Increase in blood platelets count and white blood cells
Changes in ECG heart tracing
Joint swelling, pain in extremity
Loss of appetite and/or weight loss
Muscle cramp or weakness
Ringing in the ears or spinning sensation
Stomach pain, discomfort, indigestion
Dry mouth

• RARE

Paraesthesia in mouth and lips
Rashes
Problems with coordination
Decrease in blood pressure upon standing
Disorientation
Coldness in hands and legs
Hives, allergic skin reaction
Impotence
Inability to walk due to imbalance
Inflammation of pancreas or intestine
Loss of memory
Throat tightness
Low sodium levels in the blood (hyponatremia) causing tiredness, confusion, muscle twitching, cramps

Stop taking RANOLIFE 500MG TABLET and contact your doctor immediately if you experience any of the following side effects:

Symptoms of angioedema or allergic reaction such as hives, swelling of the face, tongue or throat causing difficulty in breathing or swallowing

HOW TO MANAGE SIDE EFFECTS:-

• Headache:

Rest and relax. Drink plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.

• Nausea and Vomiting:

Take the medicine, with or just after a meal. Stick to simple meals. Avoid eating oily or spicy food.

• Constipation:

Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals. Drink plenty of water and exercise more regularly.

• Dizziness:

Try to rest and relax.et enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.

WARNING & PRECAUTIONS:-

• PREGNANCY

RANOLIFE 500MG TABLET is not recommended for use in pregnant women unless considered clearly necessary. Contact your doctor before taking RANOLIFE 500MG TABLET.

• BREASTFEEDING

RANOLIFE 500MG TABLET is not recommended for use in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before taking RANOLIFE 500MG TABLET.

• DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizziness, lightheadedness, faintness, blurred vision, confusion, hallucination, double vision and coordination problems after taking RANOLIFE 500MG TABLET.

• KIDNEY

RANOLIFE 500MG TABLET is not recommended for use in patients with severe kidney disease and should be used with caution in mild to moderate kidney disease. Contact your doctor before taking RANOLIFE 500MG TABLET.

• LIVER

RANOLIFE 500MG TABLET is not recommended for use in patients with moderate to severe liver disease and should be used with caution in mild liver disease. Contact your doctor before taking RANOLIFE 500MG TABLET.

• ALLERGY

Do not take RANOLIFE 500MG TABLET if you are allergic to Ranolazine or to lactose or other sugars or to any other ingredients of this medicine.

• HEART DISEASE

RANOLIFE 500MG TABLET should be used with caution in patients with moderate to severe heart failure, abnormal ECG changes like QT prolongation or long QT syndrome. Contact your doctor before taking RANOLIFE 500MG TABLET.

OTHERS:-

RANOLIFE 500MG TABLET is not recommended for use if you have:

Rare hereditary problems likealactose intolerance, the Lapp lactase deficiency andlucose-galactose malabsorption

• Use in pediatrics:

RANOLIFE 500MG TABLET is not recommended for use in children and adolescents under 18 years of age. Contact your doctor before taking RANOLIFE 500MG TABLET.

• Use ineriatrics:

RANOLIFE 500MG TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking RANOLIFE 500MG TABLET.

INTERACTIONS:-

• A. Drug – Drug interactions:

Before taking RANOLIFE 500MG TABLET, inform your doctor if you are taking any of the following medicine:

Medicines used to treat bacterial infections (Ex. clarithromycin, telithromycin, erythromycin)
Medicines used to treat fungal infections (Ex. itraconazole, ketoconazole, fluconazole, voriconazole, posaconazole)
Medicines used to treat HIV infection (atazanavir, nelfinavir, ritonavir, indinavir, saquinavir tenofovir disoproxil and efavirenz)
Nefazodone (used for depression)
Medicines used to treat heart problems or heart rhythm disorders (Ex. quinidine, dofetilide, sotalol, metoprolol, diltiazem, verapamil, procainamide, disopyramide)
Medicine used to prevent rejection of a transplanted organ (cyclosporine, tacrolimus, sirolimus, everolimus)
Medicines used to treat epilepsy (Ex. phenytoin, carbamazepine or phenobarbital)
Medicines used to treat tuberculosis (Ex. rifampicin, rifampin, rifabutin, rifapentine)
St. John’s Wort (herbal medicine used for depression)
Digoxin (medicines used for heart failure)
Medicines used to treat allergies (Ex. terfenadine, astemizole, mizolastine)
Medicines to treat psychoses (Ex. bupropion, imipramine, doxepin, amitriptyline, paroxetine)
Medicines used to treat cancer (Ex. cyclophosphamide)
Medicines to treat elevated cholesterol levels in the blood (Ex. simvastatin, lovastatin, atorvastatin)
Cimetidine (medicine used for stomach ulcers)
Metformin (medicines used to treat diabetes mellitus)

• B. Drug – Food interaction:

Avoid drinkingrapefruit juice with this medicine as it may lead to unwanted effects. Consult your doctor for advice.

Overdosage:

If you or anyone else accidentally takes too much of RANOLIFE 500MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are dizziness, nausea and vomiting.

SYNOPSIS:-

Drug :   Ranolzine
Pharmacological Category :   Antianginals
Therapeutic Indication :   Chronic angina
Dosage Forms :   Tablet

MORE INFORMATION:-

Keep RANOLIFE 500MG TABLET out of the sight and reach of children
Store RANOLIFE 500MG TABLET below 25°C

FAQs ABOUT RANOLIFE 500MG TABLET:-

Who should avoid taking RANOLIFE 500MG TABLET?

RANOLIFE 500MG TABLET is not recommended for use in patients with allergic history to Ranolazine or lactose or rare hereditary problems likealactose intolerance, the Lapp lactase deficiency andlucose-galactose malabsorption, severe kidney disease, moderate to severe liver disease. Contact your doctor before taking RANOLIFE 500MG TABLET.

How RANOLIFE 500MG TABLET works?

RANOLIFE 500MG TABLET works by inhibiting the entry of sodium and potassium into the heart cells, thereby preventing the calcium influx causing vasodilation and reduces ventricular tension, myocardial oxygen demand. Thus, relieving angina symptoms.

What are the side effects of taking RANOLIFE 500MG TABLET?

The most common side effects of taking RANOLIFE 500MG TABLET are nausea, vomiting, constipation, dizziness headache and feeling weak. Contact your doctor if any of the symptoms worsen.

Does RANOLIFE 500MG TABLET cause hyponatremia?

Yes. RANOLIFE 500MG TABLET may cause hyponatremia. Contact your doctor if you experience any unusual symptoms like tiredness, confusion, muscle twitching, cramps.

Can I takerapefruit juice while taking RANOLIFE 500MG TABLET?

No. Avoid drinkingrapefruit juice with this medicine as it may lead to unwanted effects. Contact your doctor before taking.

REFERENCES:-

1. KD. Tripathi. Cardiovascular drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page -554.

2. Robert J. Kizior, Keith J. Hodgson. Ranolazine. Saunders Nursing Drug Handbook 2021. 28th edition. 2021. page-1000.

3. Menarini. Pharmaceuticals Ltd. Electronic Medicines Compendium (EMC). [Revised on December 2021] [Accessed on 4th June 2022] https://www.medicines.org.uk/emc/files/pil.6442.pdf

4.ilead Sciences, Inc. U.S. Food & Drug Administration. [Revised on January 2016] [Accessed on 4th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021526s029lbl.pdf

5.ilead Sciences, Inc. Ranolazine. [Revised on April 2010] [Accessed on 4th June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d442b8c-97a8-40a9-8603-f9cd0542cedc

6. Ranolazine. Torrent Pharmaceuticals ltd. [Revised on July 2019] [Accessed on 4th June 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/1344.pdf

PRODUCT DETAILS:-

Net Qty
1 N

Item Weight
500MG

Ingredient
RANOLAZINE 500 mg

Hsn Code
30049099