NITROX XL 2.6 Tablet 30’s

INTRODUCTION

NITROX XL 2.6 contains Nitroglycerin (glyceryl trinitrate) which belongs to aroup of medicines called vasodilators. It is used to prevent and treat chest pain caused by angina pectoris. Angina pectoris is defined as a sudden, sharp, severe pain originating from the apex of heart and radiating to the left shoulder. The pain is severe and crushing, and it is characterized by feeling of pressure and suffocation, behind breastbone. It occurs when there is an inadequate supply of oxygen for the heart.

Nitroglycerin works by relaxing the blood vessels of your heart, and this reduces the strain on the heart by making it easier to pump blood. Along with the treatment, your doctor might ask you to make certain lifestyle changes such as quitting alcohol and smoking, improve your sleep at night, eating a healthy diet and manage weight.

Your doctor will decide the correct dose for you depending upon your condition. The most common side effect of taking this medicine are headache, dizziness and irregular heartbeat. Before taking this medicine, inform your doctor if you have severe anemia, increased intracranial pressure, cerebral haemorrhage, diabetes orlaucoma (increased pressure in eye). If you are pregnant or breast-feeding, ask your doctor for advice before taking this medicine. This medicine isenerally not recommended for use in children.

USES OF NITROX XL 2.6
Prevents and treats chest pain associated with angina pectoris in adults
HOW NITROX XL 2.6 WORKS

Nitroglycerin is converted into free radical nitric oxide which activates the enzymeuanylate cyclase. Activation of this enzyme leads to dephosphorylation, which relaxes vascular smooth muscles and blood vessels in your body which increases the amount of blood and oxygen flow to the heart. It reduces cardiac preload and afterload and also reduces spasm of coronary artery, decreasing systemic vascular resistance and blood pressure. This helps in relieving chest pain (angina) and in the management of blood pressure.

DIRECTIONS FOR USE

Sublingual Tablet:

Always take NITROX XL 2.6 as directed by your physician. Sit down and place 1 tablet beneath your tongue and allow it to dissolve slowly. If symptoms are not relieved, repeat the dose after 5 minutes. Do not swallow the medicine. If still pain persists after a total of 3 doses in 15 minutes, you should seek immediate medical advice. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

Oral Tablet or Capsule:

Always take NITROX XL 2.6 as directed by your physician. Swallow the medicine as a whole with alass of water. Do not crush or chew the medicine. The usual dosage is 1 or 2 tablet, three times a day, between meals. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF NITROX XL 2.6
SERIOUS
Worsening of angina symptoms such as chest pain, hypoxaemia, difficulty in breathing, cyanosis (blue colouring of the lips, fingers or toes), irregular heartbeat, weakness in one entire side of the body, slurred speech, loss of coordination and allergic skin reactions
COMMON
Dizziness or light-headedness, especially whenetting up from a sitting position
Headache
Flushing of the face
Lack of energy
HOW TO MANAGE SIDE EFFECTS

Headache: 

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

Dizziness or drowsiness:

Try to rest and relax. Avoid travelling, driving or standing for a long time. If symptoms worsen, consult your doctor immediately.

WARNING & PRECAUTIONS
PREGNANCY

NITROX XL 2.6 should be used with caution in pregnant women. Consult your doctor before taking this medicine.

BREASTFEEDING

NITROX XL 2.6 should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.

DRIVING AND USING MACHINES

Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL

Consumption of alcohol is not recommended during treatment with this medicine.

KIDNEY

NITROX XL 2.6 should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.

LIVER

NITROX XL 2.6 should be taken with caution in patients with severe liver disease. Consult your doctor for advice.

ALLERGY

Do not take this medicine if you are allergic (hypersensitive) to nitroglycerin.

HEART DISEASE

NITROX XL 2.6 should be taken with caution in patients with heart disease other than angina. Consult your doctor for advice.

OTHERS

Do not take this medicine, if you have:

Severe anemia, increased intracranial pressure, cerebral haemorrhage, diabetes orlaucoma (increased pressure in eye)
An under active thyroidland, hypothermia (low body temperature), malnutrition (poor nutrition due to an unbalanced diet) orlaucoma
INTERACTIONS

Talk to your doctor, if you are taking,

Medicines used to treat erectile dysfunction (e.g. alprostadil, sildenafil, tadalafil or vardenafil)
Other medicine used to treat angina such as long acting nitrates (isosorbide dinitrate, isosorbide mononitrate)
Medicines used to treat high blood pressure (propranolol, captopril)
Medicines used to treat depression or other mental health conditions
Medicines used to treat migraine (ergot alkaloids)
Heparin (used to thin the blood)
Apomorphine (used to treat Parkinson’s disease)
SYNOPSIS
Drug :   Nitroglycerin (Glyceryl trinitrate)
Pharmacological Category :   Vasodilators
Therapeutic Indication :  

Angina pectoris, High blood pressure, Congestive heart failure

Dosage Forms :  

Tablet, Capsule, Sublingual Tablet, Injection, Ointment, Patch, Spray

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT NITROX XL 2.6

Can I drive or ride bike while taking [GBNKYWORD]?

No. Do not drive or operate any machines while taking this medicine, because this medicine might cause dizziness.

Can I drink alcohol while taking [GBNKYWORD]?

No. Avoid consumption of alcohol while taking this medicine, because this medicine might make you feel dizzier.

What happens when I stop taking NITROX XL 2.6?

Do not stop using this medicine, without consulting your doctor. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

REFERENCES

1. KD. Tripathi. Antianginal and Other Anti-ischaemic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 542-543.

2. Thomas Michel and Brian B. Hoffman. Treatment of myocardial ischemia and Hypertension.oodman &ilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 747-753.

3. T Winsor, H J Berger. Oral nitroglycerin as a prophylactic antianginal drug: clinical, physiologic, and statistical evidence of efficacy based on a three-phase experimental design. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November 1975. [Accessed 17th November 2020] https://pubmed.ncbi.nlm.nih.gov/811102/

4. W Schneider, M Kaltenbach, B Stahl, W D Bussmann. [Anti-anginal efficacy of oral nitroglycerin. A clinical double-blind study with dose-effect relationships]. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. August 1984. [Accessed 17th November 2020] https://pubmed.ncbi.nlm.nih.gov/6430666/

5. William E Boden, Santosh K Padala, Katherine P Cabral, Ivo R Buschmann and Mandeep S Sidhu. Role of short-acting nitroglycerin in the management of ischemic heart disease. NCBI; PMC US National Library of Medicine, National Institute of Health. August 2015. [Accessed 17th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548722/

6. Kyle H. Kim; Connor C. Kerndt; Derek J. Schaller. Nitroglycerin. NCBI; StatPearls [Internet]. [Revised on July 2020] [Accessed 17th November 2020] https://www.ncbi.nlm.nih.gov/books/NBK482382/

7. Cleveland Clinic. Nitroglycerin sublingual tablets. My.Clevelandclinic.org. [Accessed 17th November 2020] https://my.clevelandclinic.org/health/drugs/20423-nitroglycerin-sublingual-tablets

8. Donald P.Page, N. Aubrey Carson, Clarence A.Buhr, Paul E.Flinn, Clyde E.Wells, Margaret T.Randall. Stability Study of Nitroglycerin Sublingual Tablets. Journel of Pharmaceutical science. Sciencedirect.com. January 2016. [Accessed 17th November 2020] https://www.sciencedirect.com/science/article/abs/pii/S0022354915400085

9. Accord. Electronic Medicines Compendium (EMC); [Revised on October 2019] [Accessed 17th November 2020] https://www.medicines.org.uk/emc/files/pil.5827.pdf

10. Pfizer. U.S. Food & Drug Administration. [Revised on May 2011] [Accessed 17th November 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021134s005lbl.pdf

USEFUL DIAGNOSTIC TESTS
Electrocardiogram (ECG)
Chest x-ray
Chest CT
Coronary CT angiography
Cardiac MRI
Coronary angiography
Echocardiogram
PRODUCT DETAILS
Net Qty
1 N
Item Weight
40
Ingredient
NITROGLYCERIN 2.6 mg
Hsn Code
30049079
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