AXOFIT PG Capsule 10’s

INTRODUCTION

AXOFIT PG CAPSULE is a combination of Alpha lipoic acid, Methylcobalamin, Folic acid, Pregabalin and Pyridoxine which belongs to the group of medicines called Antioxidants, Cyclic GABA analogues and Vitamin B complex respectively. It is used in adults to treat painful diabetic neuropathy (nerve damage occurring over time because of high sugar and fat levels in the blood due to diabetes).

The symptoms depend on the type of neuropathy, such as pain and numbness in your feet or problems with organ functions like those of your heart and bladder. Avoid consuming alcohol during treatment with GBNKEYWORD.

AXOFIT PG CAPSULE is not recommended for use in children and adolescents (younger than 18 years), so consult your doctor before taking it. Before taking AXOFIT PG CAPSULE, inform your doctor if you have any kidney, liver, heart, respiratory or nervous system problems; diabetes; or a history of alcoholism or any drug abuse or dependence.

AXOFIT PG CAPSULE should not be used in pregnant or breastfeeding women unless necessary. The most common side effects of taking AXOFIT PG CAPSULE are dizziness, drowsiness, headache, increased appetite, blurred vision, weight gain etc. Contact your doctor if any of the symptoms get worse.

USES OF AXOFIT PG CAPSULE
Treats painful diabetic neuropathy in adults
HOW AXOFIT PG CAPSULE WORKS

AXOFIT PG CAPSULE relieves nerve pain where alpha-lipoic acid reduces oxidative stress, which is considered a main pathophysiology of diabetic neuropathy development, folic acid (Vitamin B9) is found to improve the functional recovery of nerves, speed of nerve conduction and cell multiplication and methylcobalamin takes part in the production of myelin (a compound which covers and protects nerve fibres), thus restoring the damaged nerve cell. Pregabalin binds with high affinity to certain sites in the tissues of the central nervous system and acts as a growth factor for nerve cells, helping to regenerate the damaged nerve tissue and pyridoxine acts as a coenzyme in a wide range of metabolic functions affecting protein, carbohydrate and lipid utilization, like the breakdown of glycogen to glucose-1-phosphate and the synthesis of gamma-aminobutyric acid (GABA).

DIRECTIONS FOR USE

Take AXOFIT PG CAPSULE as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of AXOFIT PG CAPSULE for you based on your age, body weight and disease condition. Do not stop taking AXOFIT PG CAPSULE unless your doctor advises you to stop.

SIDE EFFECTS OF AXOFIT PG CAPSULE
COMMON
Dizziness, drowsiness, headache
Feeling elated, confused or disorientated
Decreased sexual interest, irritability
Disturbed attention, clumsiness, memory impairment or loss, shaking, trouble speaking, tingling feeling, numbness, sedation, lethargy, lack of sleep, fatigue, feeling weird
Double vision
Spinning sensation, problems with balance, fall
Increased appetite, dry mouth, constipation, vomiting, gas, diarrhoea, nausea, swollen abdomen
Difficulties with erection
Swollen body including extremities
Feeling drunk, abnormal walking style
Weight gain
Muscle cramp, joint, back or limb pain
Sore throat
UNCOMMON
Loss of appetite and weight
Low or high blood sugar
Change in self-perception, agitation, mood swings, restlessness, depression, difficulty finding words
Seeing things that are not there, unusual dreams, panic attacks, lack of interest, aggression, elevated mood
Mental impairment, trouble thinking, increased sexual interest, sexual problems including inability to achieve a sexual climax, delayed ejaculation
Changes in eyesight, unusual eye movement, tunnel vision, flashes of light
Jerky movements, reduced reflexes, increased activity, dizziness on standing, skin sensitivity
Taste loss, burning sensation, shaking on movement, low or loss of consciousness, increased noise sensitivity, feeling unwell
Eye swelling, pain, weakness, watering, irritation or dryness
Heart rhythm changes, increased heart rate, low or high blood pressure, changes in heartbeat, heart failure
Flushing, hot flushes
Nasal dryness or congestion
Increased salivation, heartburn, numbness around the mouth
Sweating, rash, chills, fever
Muscle twitching, swollen joints, stiff muscle, muscle or neck pain
Breast pain
Troubled or painful urination, incontinence
Weakness, thirst, chest tightness
Changes in blood and liver test results (high blood creatinine phosphokinase, alanine aminotransferase, aspartate aminotransferase, blood creatinine and low platelet count, neutrophils and blood potassium)
Hypersensitivity, swollen face, itchiness, hives, cough, snoring, runny nose, nosebleed
Painful menstrual periods
Cold hands and feet
RARE
Abnormal sense of smell, swinging vision, changed the perception of depth, visual brightness, vision loss
Dilated pupils, cross eyes
Cold sweat, throat tightness
Pancreatic inflammation
Trouble swallowing
Slow or decreased body movement
Trouble writing properly
Increased abdominal fluid
Fluid in the lungs
Muscle damage
Breast discharge, unusual breast growth, breast enlargement in men
Interrupted menstrual periods
Decreased white blood cell count
Inappropriate behaviour
Allergic reactions (trouble breathing, eye inflammation, a serious skin reaction characterized by rash, blisters, peeling skin and pain)
Jaundice (yellow skin and eyes)

Stop taking AXOFIT PG CAPSULE and contact your doctor immediately if you experience any of the following side effects:

Swollen face
Skin turning red and starting to blister or peel
Allergic reaction (swelling of the face, lips, tongue and throat, diffuse skin rash)
Blurring or loss of eyesight or other changes in vision
Kidney failure, reduced urine volume
Thoughts of harming or killing self
Constipation
Fits
Trouble breathing or shallow breaths
HOW TO MANAGE SIDE EFFECTS

Nausea:

Take AXOFIT PG CAPSULE with or just after, meals. Stick to simple meals. Avoid eating oily or spicy foods. If you still feel nauseous, contact your doctor.

Vomiting:

Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like eating; you don’t have to eat or avoid any specific foods. If vomiting does not improve, contact your doctor.

Constipation:

Eat plenty of fibre-rich foods like fresh fruits and vegetables and cereals and drink plenty of water. Exercise more regularly. If you still feel constipated, contact your doctor.

Diarrhea:

Drink lots of fluids, like water or fruit juice, to keep yourself hydrated. Ask your doctor before taking any medicine for diarrhea. If diarrhoea does not improve, contact your doctor.

Gas:

Eat smaller and more frequent meals. Eat and drink slowly and exercise regularly. If flatulence does not improve, contact your doctor.

Headache:

Drink plenty of water and get adequate rest. Try to be relaxed and stress-free. Check with your doctor before taking any medicine for a headache. If your headache does not improve, consult your doctor.

Dizziness:

Lie down until the dizziness is resolved, then get up slowly. Do not hurry and move slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and drugs. If dizziness does not improve, consult your doctor.

WARNING & PRECAUTIONS
PREGNANCY

AXOFIT PG CAPSULE is not recommended for use in pregnant women unless considered necessary. Females of child-bearing capability must use effective contraception. Consult your doctor before taking it.

BREASTFEEDING

AXOFIT PG CAPSULE is not recommended for use in breastfeeding women unless considered necessary. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you experience dizziness, sleepiness or decreased concentration after taking AXOFIT PG CAPSULE.

ALCOHOL

Avoid consumption of alcohol while taking AXOFIT PG CAPSULE. Let your doctor know if you have a history of alcoholism.

KIDNEY

AXOFIT PG CAPSULE should be taken with caution in patients with kidney disease or impairment. Consult your doctor before taking it.

LIVER

AXOFIT PG CAPSULE should be taken with caution in patients with liver disease. Consult your doctor before taking it.

ALLERGY

Do not take AXOFIT PG CAPSULE if you are allergic to Alpha lipoic acid, Methylcobalamin, Folic acid, Pregabalin, Pyridoxine or any of the other ingredients of AXOFIT PG CAPSULE.

LUNGS

AXOFIT PG CAPSULE should be taken with caution in patients with respiratory disorders. Consult your doctor before taking it.

HEART DISEASE

AXOFIT PG CAPSULE should be taken with caution in patients with a history of heart disease or who received a coronary stent (a tube inserted in the artery that leads to the heart, to prevent blockages). Consult your doctor before taking it.

OTHERS

Before taking AXOFIT PG CAPSULE, inform your doctor if you:

Have diabetes (high blood sugar)
Are prone to constipation
Have a history of any drug abuse or dependence
Have nervous system disorders
Have a folate-dependent tumour

Use in Pediatrics:

AXOFIT PG CAPSULE is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking it.

Use in Geriatrics:

AXOFIT PG CAPSULE should be used with caution in elderly patients (aged above 75 years) with kidney problems and the elderly in general as it causes dizziness and sleepiness which could increase the occurrence of accidental injury (fall) in them. Consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug interactions:

Before taking AXOFIT PG CAPSULE, inform your doctor if you are taking any of the following medicines:

Oxycodone (used to treat severe pain)
Lorazepam (used to treat anxiety)
Medicines containing alcohol

Overdosage:

If you or anyone else accidentally took too much of AXOFIT PG CAPSULE, contact your doctor immediately. Symptoms of AXOFIT PG CAPSULE overdose are sleepiness, confusion, agitation, restlessness or fits.

SYNOPSIS
Drug :   Alpha Lipoic Acid, Methylcobalamin, Folic Acid, Pyridoxine, Pregabalin
Pharmacological Category :   Antioxidants, Vitamins, Cyclic GABA analogues
Therapeutic Indication :   Painful diabetic neuropathy
Dosage Forms :   Tablet, Capsule
MORE INFORMATION
Keep AXOFIT PG CAPSULE out of reach from children
Store AXOFIT PG CAPSULE below 25°C
FAQs ABOUT AXOFIT PG CAPSULE

Q: Can I take AXOFIT PG CAPSULE if I have diabetes?

A: Before taking AXOFIT PG CAPSULE, inform your doctor if you have diabetes and about the medicines you are taking for it, as according to current clinical practice, some diabetic patients who gain weight on AXOFIT PG CAPSULE treatment may need to adjust the doses of their anti-diabetic medicines.

Q: Can AXOFIT PG CAPSULE make me feel suicidal?

A: Thoughts of harming or killing oneself are seen in a small number of patients being treated with AXOFIT PG CAPSULE. If at any time you have such thoughts, immediately contact your doctor or go to the nearest hospital.

Q: Can AXOFIT PG CAPSULE be taken during pregnancy?

A: AXOFIT PG CAPSULE should not be used in pregnant women unless necessary. Females who are of childbearing age must use effective contraception. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before taking AXOFIT PG CAPSULE. Inform your doctor immediately if you become pregnant during treatment with AXOFIT PG CAPSULE.

Q: Can AXOFIT PG CAPSULE cause constipation?

A: AXOFIT PG CAPSULE may cause constipation and other gastrointestinal problems like blocked or paralysed intestines when taken with other medicines (like some types of pain medicines). In such cases, eat plenty of fibre-rich foods, such as fresh fruits, vegetables and cereals and drink plenty of water. Inform your doctor if you feel constipated, especially if you are prone to this problem.

Q: Can I drink alcohol during treatment with AXOFIT PG CAPSULE?

A: Avoid drinking alcohol during treatment with AXOFIT PG CAPSULE and inform your doctor if you have a history of alcoholism.

Q: Can AXOFIT PG CAPSULE be given to children?

A: No. AXOFIT PG CAPSULE is used for adults and not recommended for children and adolescents below 18 years of age, as the safety and efficacy of AXOFIT PG CAPSULE in this age group have not been established. Your doctor will select a suitable alternative treatment for your child.

Q: Can I take AXOFIT PG CAPSULE on an empty stomach?

A: Take AXOFIT PG CAPSULE as advised by your physician. You take it with or without food. However, if you feel nauseous, take AXOFIT PG CAPSULE with meals or just after meals.

Q: What if I forget to take a dose of AXOFIT PG CAPSULE?

A: If you forget to take a dose of AXOFIT PG CAPSULE, take it as soon as you remember. However, omit the missed dose if it is almost time for the next one. Do not take AXOFIT PG CAPSULE twice to make up for the missed dose.

Q: Can I stop taking AXOFIT PG CAPSULE on my own?

A: Continue taking AXOFIT PG CAPSULE until your doctor tells you to stop, unless you experience any unwanted effects, a worsening of your condition or any new symptoms. In such a case, contact your doctor. Your doctor will advise you to stop taking AXOFIT PG CAPSULE gradually over a period of at least one week.

Q: Can AXOFIT PG CAPSULE discontinuation cause withdrawal symptoms?

A: After stopping AXOFIT PG CAPSULE treatment, you may experience certain side effects like trouble sleeping, headache, nausea, anxiety, diarrhoea, flu-like symptoms, fits, nervousness, depression, pain, sweating and dizziness. There are more chances of getting these symptoms if you have been taking this medicine for a longer period. If you have any further doubts regarding the use of AXOFIT PG CAPSULE, ask your doctor.

Q: How should AXOFIT PG CAPSULE be taken? Can it be crushed?

A: No. Do not break, crush or chew AXOFIT PG CAPSULE. Take it as advised by your physician. Swallow it with a glass of water. Your doctor will determine the correct dose and duration for you based on your age, body weight and disease condition.

REFERENCES

1. KD Tripathi. Antiepileptic Drugs. Drugs Affecting Blood and Blood Formation. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 420, 608.

2. Serhiyenko V, Serhiyenko L, Suslik G et al. Alpha-lipoic acid: mechanisms of action and beneficial effects in the prevention and treatment of diabetic complications. MOJ Public Health. MedCrave. July 2018. [Accessed on 2nd August 2022] https://medcraveonline.com/MOJPH/alpha-lipoic-acid-mechanisms-of-action-and-beneficial-effects-in-the-prevention-and-treatment-of-diabetic-complications.html

3. Kang WB, Chen YJ, Lu DY, Yan JZ. Folic acid contributes to peripheral nerve injury repair by promoting Schwann cell proliferation, migration and secretion of nerve growth factor. NIH National Library of Medicine, National centre for biotechnology information. PubMed Central. January 2019. [Accessed on 2nd August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263007/

4. Vasudevan D, Naik MM, Mukaddam QI. Efficacy and safety of methylcobalamin, alpha lipoic acid and pregabalin combination versus pregabalin monotherapy in improving pain and nerve conduction velocity in type 2 diabetes associated impaired peripheral neuropathic condition. [MAINTAIN]: Results of a pilot study. NIH National Library of Medicine, National canter for biotechnology information. PubMed Central. January 2014. [Accessed on 2nd August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992764/

5. Innova Captab Ltd. Alpha Lipoic Acid + Methylcobalamin + Folic Acid + Pregabalin + Pyridoxine. [Revised in May 2021] [Accessed on 2nd August 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2732.pdf

6. Micro Labs Ltd. Alpha Lipoic Acid + Methylcobalamin + Folic Acid + Pregabalin + Pyridoxine. [Accessed on 2nd August 2022] https://www.microlabsltd.com/elibrary/node/1891

USEFUL DIAGNOSTIC TESTS
Nerve conduction testing
Electromyography
Net Qty
1 N
Item Weight
17.5 g
Ingredient
ALPHA LIPOIC ACID 100 mg+FOLIC ACID 1.5 mg+METHYLCOBALAMIN 750 MCG+PREGABALIN 75 mg+PYRIDOXINE 3 mg
Hsn Code
30049099
Show more