Aparin 0.5mg Tablet 10’S

INTRODUCTION

APARIN 0.5MG TABLET contains Azathioprine which belongs to the group of medicines called Immunosuppressants. Azathioprine is used to help the body to accept a kidney, liver, heart, lung, or pancreas transplant.

It is also used for severe rheumatoid arthritis, inflammation of the gut, and to treat some diseases where the immune system is reacting against its own body (autoimmune disease) including severe inflammatory diseases of the liver, arteries, skin, and some blood disorders.

APARIN 0.5MG TABLET is not recommended to use when allergic to Azathioprine, mercaptopurine (a medicine used to treat leukemia, a cancer of the white blood cells), or any of the other ingredients of this medicine.

APARIN 0.5MG TABLET is not recommended to use in pregnant or intend to become pregnant and breastfeeding women. Consult your doctor for advice before taking the medicine.

The most common side effects of taking APARIN 0.5MG TABLET are low white blood cell levels in your blood tests, which may cause an infection and nausea (feeling sick). Consult your doctor for advice if any of the above side effects worsen or persist for a longer duration.

USES OF APARIN 0.5MG TABLET

It is used to:

Prevent organ rejection in transplant patients (kidney, liver, heart, lung, or pancreas)
Treat rheumatoid arthritis  
Treat systemic lupus erythematosus
HOW APARIN 0.5MG TABLET WORKS

APARIN 0.5MG TABLET belongs to immunosuppressants which reduces the action of body’s own defense system (the immune system) and prevents rejection of the transplanted organ. It also blocks the action of certain chemical messengers that are responsible for inflammation, swelling, and redness associated with certain joint diseases.

DIRECTIONS FOR USE

Take APARIN 0.5MG TABLET as advised by your physician. Swallow the APARIN 0.5MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight, and disease condition.

SIDE EFFECTS OF APARIN 0.5MG TABLET
COMMON
Infections
Reduction in the number of  blood platelets
Increases the risk of bleeding or bruising
Decrease in red blood cells in the blood (anemia)
Nausea, vomiting
Loss of appetite  
Increased infections in patients with bowel inflammation
Decrease in the number of the white blood cells in patients with rheumatoid arthritis
Liver disease
Inflammation of the pancreas, which causes severe pain in the back and abdomen
UNCOMMON
Blood disorder after transplant surgery
Foul-smelling in the stools which are bulky, loose, and greasy
Hair loss
Liver problems in patients with rheumatoid arthritis
RARE
Stomach ulcers (which can bleed) and disease which may cause heartburn, vomiting, general discomfort in the stomach
Bowel problems leading to diarrhea, abdominal pain, and constipation
Blood and bone marrow disorders
Exposure to sunlight can cause skin discoloration or a rash
Different types of cancers including blood, lymph, and skin cancers

Stop taking APARIN 0.5MG TABLET and contact your doctor immediately if you experience any of the following side effects:

Tiredness, dizziness, nausea, vomiting, diarrhea, or abdominal pain
Swelling of the eyelids, face, or lips
Redness of the skin nodules or a skin rash  
Pain in muscles or joints
Sudden wheeziness, coughing, or difficulty in breathing
Increased temperature, or other signs of an infection such as sore mouth, sore throat, urinary problems, or chest infection causing breathlessness and cough
Problems with liver, signs include skin or whites of eyes turn yellow (jaundice)
Rash (increased pink,  red, or purple lumps which are sore to touch), particularly on your hands, arms, fingers, face, and neck, which may also be accompanied by a fever
HOW TO MANAGE SIDE EFFECTS

Nausea or Vomiting:

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods.

Constipation:

Eat plenty of fiber-rich foods such as fresh fruits, vegetables, and cereals, and drink plenty of water. Exercise more regularly.

WARNING & PRECAUTIONS
PREGNANCY

APARIN 0.5MG TABLET is not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking it.

BREASTFEEDING

APARIN 0.5MG TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizzy after taking APARIN 0.5MG TABLET. Consult your doctor before taking it.

ALCOHOL

Avoid consumption of alcohol while taking APARIN 0.5MG TABLET. Consult your doctor before taking it.

KIDNEY

APARIN 0.5MG TABLET should be taken with caution in patients with kidney problems. Consult your doctor before taking.

LIVER

APARIN 0.5MG TABLET is not recommended for use in patients with severe liver disease. Consult your doctor before taking.

ALLERGY

Do not take APARIN 0.5MG TABLET, if you are allergic to Azathioprine or 6-mercaptopurine or any of the other ingredients of this medicine.

OTHERS

APARIN 0.5MG TABLET is not recommended for use if you have:

Severe infection
Severe bone marrow disease
Metabolic abnormality called Lesch-Nyhan syndrome

Before taking APARIN 0.5MG TABLET, inform your doctor if you:

Ever suffered from chickenpox or shingles
Have TPMT or NUDT15 deficiency
Have higher risk of infections
Have hair loss
Have tumors, including skin cancer
Have lymphoproliferative disorders
Have Macrophage Activation Syndrome (excessive activation of white blood cells associated with inflammation) causes certain types of arthritis
Have increased risk of developing lymphoma
Have hepatosplenic T-cell lymphoma (HSTCL), a rare type of T-cell lymphoma
Have Crohn’s disease or ulcerative colitis
Have severe leukopenia, thrombocytopenia, anemias including macrocytic anemia, and/or pancytopenia

Use in pediatrics:

Safety and efficacy of APARIN 0.5MG TABLET in pediatric patients have not been established. Consult your doctor before taking it.

Use in geriatrics:

APARIN 0.5MG TABLET should be used with caution in elderly patients. Consult your doctor before taking it.

INTERACTIONS

A. Drug-Drug interactions:

Medicines used to treat viral infections (Ex. ribavirin)
Immunosuppressants (Ex. ciclosporin, methotrexate, tacrolimus)
Medicines to treat cancer (Ex. Doxorubicin)
Allopurinol, oxipurinol or thiopurinol, or other xanthine oxidase inhibitors, such as febuxostat (for gout or kidney stones)
Cimetidine (for gut or stomach ulcers)
Furosemide (water medicine )
Penicillamine (used for rheumatoid arthritis)
Anticoagulants such as warfarin or acenocoumarol (used to thin the blood)
Captopril (used for blood pressure or heart failure)
Indomethacin (an anti-inflammatory)
Co-trimoxazole (an antibiotic)
Infliximab, mesalazine, olsalazine, sulfasalazine, or balsalazide (used to treat ulcerative colitis or Crohn’s disease)

Overdosage:

If you or anyone else accidentally takes too much of APARIN 0.5MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose include nausea, vomiting and diarrhea, and lack of white blood cells which may cause frequent infections such as fever, severe chills, sore throat or mouth ulcers, disturbances of your liver function, bruising, and bleeding.

SYNOPSIS
Drug :   Azathioprine
Pharmacological Category :   Immunosuppressants
Therapeutic Indication :   Prevention of organ rejection in transplant patients, Treatment of Rheumatoid arthritis
Dosage Forms :   Tablet
MORE INFORMATION
Keep APARIN 0.5MG TABLET reach out of children
Store at room temperature
FAQs ABOUT APARIN 0.5MG TABLET

Does APARIN 0.5MG TABLET increase the chance of infections?

It may cause leukopenia (decreased number of white blood cells) and hence makes more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising.

Is APARIN 0.5MG TABLET safe to take during pregnancy?

No, it is not safe to take APARIN 0.5MG TABLET during pregnancy. Consult your doctor before taking it.

Is APARIN 0.5MG TABLET can be stopped at any time?

No. Do not stop taking APARIN 0.5MG TABLET without consulting your doctor as you may need to take it indefinitely to help stop transplant rejection.

How long do I need to take APARIN 0.5MG TABLET?

The duration varies from person to person as it is prescribed depending upon the patient’s medical condition.

What should I do if I forget a dose of APARIN 0.5MG TABLET?

If you miss a dose of APARIN 0.5MG TABLET, take the dose as soon as you remember it. Do not take a double dose to make up for a missed one.

Is breastfeeding safe during APARIN 0.5MG TABLET treatment?

No, breastfeeding should be avoided, while taking this medicine, since it may harm the baby and cause serious side effects. Consult your doctor before taking.

REFERENCES

1. Alan M. Krensky, Jamil R. Azzi, and David A. Hafler. Immunosuppressants and Tolerogens. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018 Page – 637-653.

2. Murray  JE, Merrill JP, Harrison JH, Wilson RE, Dammin GJ. Prolonged survival of human-kidney homografts by immunosuppressive drug therapy. N. Engl. J. Med. 1963; 268:1315–1323.

3. Mylan Ltd. Electronic Medicines Compendium (EMC). [Revised in August 2011] [Accessed 27th April 2021] https://www.medicines.org.uk/emc/product/2540/smpc

4. Mylan Ltd. Electronic Medicines Compendium (EMC). [Revised in August 2011] [Accessed 27th April 2021] https://www.medicines.org.uk/emc/files/pil.3301.pdf

5. Salix Pharmaceuticals. [Revised in 2021] [Accessed 27th April 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=9050af7a-19c6-4670-937a-9445605de995&type=display

USEFUL DIAGNOSTIC TESTS
Rheumatoid Factor – Agglutination
Rheumatoid Factor – Turbidometry
Rheumatoid Factor IgG Antibody
PRODUCT DETAILS
Net Qty
1 N
Item Weight
17.5 g
Ingredient
AZATHIOPRINE 50MG
Hsn Code
30049099
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