Amicon 25mg Tablet 10’S

INTRODUCTION

AMICON 25MG TABLET contains Amitriptyline which belongs to the group of medicines called Antidepressants. It is used to treat depression. It is also used to treat neuropathic pain and prevents chronic headache and migraine.

Depression is a mood disorder that causes a persistent feeling of sadness and loss of interest which affects how you feel, think or behave that leads to a variety of emotional and physical problems in the affected person.

Using AMICON 25MG TABLET should not be stopped suddenly, your physician may advise you to reduce dose gradually to overcome withdrawal symptoms.

AMICON 25MG TABLET is not recommended for use in patients suffering from mania and or having heart problems such as heart attack, disturbances in heart rhythm, heart block or coronary artery disease, irregular heartbeat and or congestive heart failure and severe liver disease.

Before taking AMICON 25MG TABLET, inform your doctor if you are suffering from epilepsy (seizures), depression, severe low blood pressure, bipolar disorder, urinary retention and or kidney problems.

AMICON 25MG TABLET is not recommended for use in pregnant women during first and third trimester period and breastfeeding women. It is also not recommended for children and adolescents (below 18 years). Consult your doctor before taking the medicine.

The most common side effects of taking AMICON 25MG TABLET are weight gain, gastrointestinal symptoms like constipation, sleepiness, drowsiness, dizziness, headache, dry mouth, slurred or slow speech. Consult your doctor if any of these above symptoms gets worse.

USES OF AMICON 25MG TABLET

It is used to treat:

Depression
Neuropathic pain
Chronic headache and migraine
HOW AMICON 25MG TABLET WORKS

AMICON 25MG TABLET prevents the reuptake and hence the inactivation of neurotransmitters noradrenaline and serotonin, that are present at the nerve terminals in our brain. Reuptake prevention of these monoamine neurotransmitters potentiate their action in the brain. This appears to be associated with the antidepressant activity and helps in regulating the mood. It also stops the transmission of pain signals from nerves to the brain thereby relieving neuropathic pain due to damaged nerves.

DIRECTIONS FOR USE

Take AMICON 25MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF AMICON 25MG TABLET
COMMON
Sleepiness  
Shakiness of hands or other parts of the body
Dizziness
Headache
Irregular, hard or rapid heartbeat
Dry mouth
Constipation
Nausea
Excessive sweating
Weight gain
Slurred or slow speech
Aggression
Problem with ability of the eye to change its focus from distant to near objects (and vice versa)
Congested nose
Confusion
Sexual disturbances (problems with erection, decreased sex-drive)
Changes in taste
Numbness or tingling in the legs or arms
Signs of low sodium concentration in blood such as nausea, vomiting, headache and confusion
Urination disorder
Feeling thirsty
Agitation
Disturbed coordination
Dilated pupils
UNCOMMON
Excitement, anxiety, difficulties sleeping, nightmares
Convulsions
Tinnitus (ringing in ears)
Increased blood pressure
Skin rash, nettle rash (urticaria), swelling of the face and tongue
Difficulties passing urine
Breast milk outflow without breast feeding or increased production of breast milk
Collapse conditions
Liver function impairment such as cholestatic liver disease
RARE
Decreased appetite
Delirium (especially in elderly patients), hallucinations
Swelling of the salivary glands
Hair loss
Increased sensitivity to sunlight
Breast enlargement (men)
Fever
Weight loss
Abnormal results of liver function tests

Stop taking AMICON 25MG TABLET and contact your doctor immediately if you experience any of the following side effects:

Signs of a severe allergic reactions such as difficulty breathing or swelling of your face, lips, throat or tongue
Signs of acute glaucoma (eye disorder) such as attacks of intermittent blurring of vision, rainbow vision and eye pain
Irregular heart rhythm
Signs of paralyzed intestine such as bad constipation, a swollen stomach, fever and vomiting
Yellowing of the skin and the white in the eyes
Signs of blood or bone marrow being affected with symptoms such as bruising, bleeding, pallor or persistent sore throat and fever
Self-harming thoughts
HOW TO MANAGE SIDE EFFECTS

Headache:

Rest and relax. Drink plenty of fluids such as water abnormal. Apply a pain-relieving balm on the head if required. Do not consume alcohol. Consult your doctor if the symptom did not improve.

Diarrhea:

Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhoea. Consult your doctor if the symptom did not improve.

Nausea or Vomiting:

Take this medicine with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if the symptom did not improve.

Constipation:

Eat more fiber especially soluble fiber foods like beans, oats, oat bran, rice bran, barley, citrus fruits, apples, strawberries. Keep yourself hydrated. Avoid taking any medicine on your own for treating constipation. Consult your doctor if the symptom did not improve.

Dizziness:

If you feel dizzy, keep your eyes closed sit or lie down. Do not drive or operate machinery. Consult your doctor if the symptom did not improve.

WARNING & PRECAUTIONS
PREGNANCY

AMICON 25MG TABLET is not recommended for use in pregnant women during first and third trimester. Consult your doctor before taking it.

BREASTFEEDING

AMICON 25MG TABLET is not recommended for use in breastfeeding women unless it is clearly necessary. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel drowsiness and dizziness after taking AMICON 25MG TABLET.

ALCOHOL

Avoid consumption of alcohol while taking AMICON 25MG TABLET because it might increase the sedative effects.

KIDNEY

[GNBKEYWORD] should be used with caution in patients with chronic renal failure. Consult your doctor before taking AMICON 25MG TABLET.

LIVER

AMICON 25MG TABLET is not recommended for use in patients with severe liver disease. It should be used with caution in patients with mild to moderate liver diseases. Consult your doctor before taking.

ALLERGY

Do not take AMICON 25MG TABLET if you are allergic to Amitriptyline, other tricyclic antidepressants or to any of the other ingredients of this medicine.

HEART DISEASE

AMICON 25MG TABLET is not recommended for use in patients with heart problems such as heart attack (myocardial infarction), disturbances in heart rhythm, heart block or coronary artery disease, irregular heartbeat and congestive heart failure. Consult your doctor before taking.

OTHERS

AMICON 25MG TABLET is not recommended for use if you:

Are suffering from mania

Before taking AMICON 25MG TABLET, inform your doctor if you have:

Epilepsy
Depression or anxiety
Porphyria (blood disorder)
Pheochromocytoma (tumor of the adrenal gland)
Blood dyscrasias (blood disorder)
Urinary retention
Prostatic hypertrophy (enlarged prostate) such as frequent or urgent need to urinate, increased frequency of urination at night and difficulty while urinating
Increased intra-ocular pressure or narrow angle glaucoma
Signs of hyperthyroidism (overactive thyroid) such as unintentional weight loss, increased appetite, nervousness
Severe low blood pressure
Planned for surgery
Signs of hyponatremia (low sodium level in blood) such as nausea, vomiting, headache., confusion
Difficulty in passing urine
Thyroid disease
Bipolar disorder
Schizophrenia (serious mental disorder)
Narrowing of the gastric outlet (pylorus stenosis) and blocked intestine (paralytic ileus)
Diabetes

Use in pediatrics:

AMICON 25MG TABLET is not recommended for use in children and adolescents below 18 years of age. Consult your doctor before taking the medicine.

Use in geriatrics:

AMICON 25MG TABLET should be used with caution in elderly aged above 65 years. Consult your doctor before taking the medicine.

INTERACTIONS

A. Drug – Drug interactions:

Before taking AMICON 25MG TABLET, inform your doctor if you are taking:

Medicines used to treat depression. Ex. phenelzine, iproniazid, isocarboxazid, nialamide, tranylcypromine, paroxetine, fluoxetine, fluvoxamine, duloxetine, bupropion
Selegiline (used to treat Parkinson’s disease)
Adrenaline, ephedrine, isoprenaline, noradrenaline, phenylephrine and phenylpropanolamine (used as anesthetics)
Calcium-channel blockers (used to treat high blood pressure) Ex. verapamil and diltiazem
Guanethidine, betanidine, clonidine, reserpine and methyldopa (medicines used in the treatment of high blood pressure)
Anticholinergic drugs (used to treat Parkinson’s disease and gastrointestinal disorders) Ex. atropine, hyoscyamine
Thioridazine (used in the treat schizophrenia)
Nefopam, tramadol and morphine (used to reduce pain)
Medicines to treat fungal infections (Ex. fluconazole, terbinafine, ketoconazole and itraconazole)
Sedatives (used in treatment of pain) such as barbiturates Ex. amobarbital, butabarbital 
Buprenorphine / opioids (used for severe pain or opioid drug addiction)
Medicines used to treat diseases associated with heart such as beta blockers (Ex. acebutolol, atenolol) and antiarrhythmics (Ex. disopyramide, flecainide)
Cimetidine (used to treat stomach ulcers)
Alpha2-adrenoceptor stimulants used to treat attention-deficit/hyperactivity disorder Ex. methylphenidate
Ritonavir (used to treat HIV)
Oral contraceptives (used to inhibit pregnancy) Ex. estrogens and progestogens
Rifampicin (to treat bacterial infections)
Phenytoin and carbamazepine (used to treat epilepsy)
St. john´s wort (herbal medicine used to treat depression)
Thyroid medication (used to abnormal thyroid) Ex. thyroxine
Medicines to treat irregular heartbeats (Ex. quinidine and sotalol)
Astemizole and terfenadine (used to treat allergies and hay fever)
Medicines used to treat mental illnesses Ex. pimozide and sertindole
Cisapride (used to treat certain types of indigestion)
Halofantrine (used to treat malaria)
Methadone (used as detoxicant and to treat pain)
Diuretics (used to treat hypertension) Ex. furosemide
Altretamine (used to treat cancer of the ovaries)
Disulfiram (used to treat chronic alcoholism)
Dopaminergics (used to treat Parkinson’s disease and restless legs syndrome)
Baclofen (used as muscle relaxant)
Nitrate medicine (used to treat angina) Ex. glyceryl trinitrate
Sibutramine (used as an anti-obesity medicine)

Over dosage:

If you or anyone else accidentally takes too much of AMICON 25MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose include dilated pupils, fast or irregular heartbeats, dry mouth and tongue, fever, agitation, difficulty breathing, blue discoloration of the skin, confusion, hallucinations, disturbed concentration, fast heartrate, uncontrolled movements, difficulties passing water, intestinal blockage, fits, low blood pressure, weak pulse, pallor, decreased heart rate, drowsiness, impaired conduction of heart, hypokalemia, drowsiness, hypothermia, hyperactive reflexes, muscle rigidity and vomiting.

SYNOPSIS
Drug :   Amitriptyline
Pharmacological Category :   Anti-depressants
Therapeutic Indication :   Depression, Neuropathic pain, Migraine           
Dosage Forms :   Tablet
MORE INFORMATION
Keep AMICON 25MG TABLET out of reach of children
Store below 25°C
FAQs ABOUT AMICON 25MG TABLET

Can AMICON 25MG TABLET make you more depressed after a while or make your condition worse?

Taking AMICON 25MG TABLET can’t make your mood worse. But it may have side effects that can change or alter your mood. Consult your doctor if you get any extreme thoughts, mood swings or unusual changes in behavior in the first weeks after taking AMICON 25MG TABLET.

How much dose of AMICON 25MG TABLET can I take in a day?

Take AMICON 25MG TABLET as advised by your physician. Do not crush or chew the medicine. Swallow the medicine with glass of water. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Is AMICON 25MG TABLET an antibiotic?

No, AMICON 25MG TABLET is not an antibiotic. AMICON 25MG TABLET belongs to group of medicines called antidepressants which is used to treat major depressive episodes of depression and neuropathic pain in adults which is also used to prevent chronic headache and migraine.

Can I consume alcohol after taking AMICON 25MG TABLET?

Sleepiness or drowsiness is the common side effect of AMICON 25MG TABLET. Since alcohol has sedative effect or it induces sleep, alcohol is not recommended for use after taking AMICON 25MG TABLET.

Can AMICON 25MG TABLET be used in pregnancy?

AMICON 25MG TABLET is not recommended for use in pregnancy during first and third trimester. Stop taking this medicine if you become pregnant. Consult your doctor before taking AMICON 25MG TABLET.

REFERENCES

1. K.D. Tripathi. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs. Essentials of medical pharmacology. Seventh edition. 2013 Page 455.

2. Amit Thour, Raman Marwaha. Amitriptyline. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls. [Revised on May 2022] [Accessed on 26th April 2022] https://www.ncbi.nlm.nih.gov/books/NBK537225/

3. M Sandoz, S Vandel, B Vandel, B Bonin, B Hory, Y St Hillier, R Volmat. Metabolism of amitriptyline in patients with chronic renal failure. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. [Revised on 1984] [Accessed on 26th April 2022] https://pubmed.ncbi.nlm.nih.gov/6723762/

4. DOUGLAS M. MAURER; TYLER J. RAYMOND; and BETHANY N. DAVIS. Depression: Screening and Diagnosis, American Family Physician Organization. [Revised Oct 2018] [Accessed on 26th April 2022] https://www.aafp.org/afp/2018/1015/p508.htm

5. Pharmascience INC. Drug and Health Product Register [Revised Sep 2017] [Accessed on 26th April 2022] https://pdf.hres.ca/dpd_pm/00041275.PDF

6. Sandoz INC. Food and Drugs Administration (FDA) [Revised May 2014] [Accessed on 26th April 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/085966s095,085969s084,085968s096,085971s075,085967s076,085970s072lbl.pdf

7. Brown & Burk UK Ltd. Electronic Medicines Compendium (EMC) [Revised Jan 2022] [Accessed on 26th April 2022] https://www.medicines.org.uk/emc/files/pil.10849.pdf

PRODUCT DETAILS
Net Qty
1 N
Item Weight
17.5 g
Ingredient
AMITRIPTYLINE 25MG
Hsn Code
30049099
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